Overview

• A genome-wide scan of nearly one million participants in Finland and the U.K. uncovered 53 lead variants associated with frailty, including 45 loci never before reported.
• Researchers integrated the Hospital Frailty Risk Score with FinnGen and UK Biobank data to link genetic signals to immune, neural, and metabolic pathways.
• Colocalization analyses and proteomic integration confirmed causal roles for CGREF1, APOE, and PPP6C in driving frailty.
• Ongoing work focuses on validating polygenic frailty scores in independent cohorts to refine individual risk prediction.
• Plans are underway to design early intervention trials aimed at middle-aged adults identified as high risk by their genetic profiles.