Overview

• Plasma-activated medium (PAM) reduced synovial sarcoma tumor volume by 54% and tumor weight by 41% in mouse models after four weeks of daily injections.
• In vitro studies showed only 21% of synovial sarcoma cells survived after exposure to PAM prepared with five minutes of plasma irradiation.
• The treatment selectively induces apoptosis in cancer cells through reactive oxygen and nitrogen species, sparing healthy cells and minimizing systemic toxicity.
• Mice treated with PAM exhibited no observable side effects, such as weight loss or appetite changes, underscoring its safety profile.
• Researchers aim to refine plasma generation parameters and explore combination therapies to advance PAM toward clinical trials for this aggressive cancer.