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2mo ago

Pioneering CAR T-cell Therapy Achieves Record 18-Year Cancer Remission

A woman treated as a child for neuroblastoma with experimental CAR T-cell therapy remains cancer-free nearly two decades later, offering hope for solid tumor treatments.

Overview

  • The patient, diagnosed with neuroblastoma at age 4, received CAR T-cell therapy after standard treatments failed to stop the cancer's spread.
  • This marks the longest reported remission for a solid tumor following CAR T-cell therapy, a treatment typically more effective against blood cancers.
  • CAR T-cell therapy involves genetically engineering a patient’s T-cells to target and destroy cancer cells, then reinfusing them into the body.
  • The patient has remained cancer-free for over 18 years, had two full-term pregnancies, and shows no signs of recurrence without additional treatments.
  • Researchers are now working to improve CAR T-cell therapy for broader effectiveness against solid tumors, as current response rates vary significantly among patients.