Particle.news
Download on the App Store
6 ARTICLES
·
1h ago

Pilot Trial Suggests PGT-A May Shorten Time to Pregnancy for Women 35–42

Current UK guidance remains unchanged as evidence is preliminary.

Almost 21,000 babies were born from IVF in 2023, compared to 8,700 in 2000, the Human Fertilisation and Embryology Authority (HFEA) has said. (Photo by Philippe Lopez/AFP)
Image

Overview

  • A single-centre randomized pilot at King's Fertility enrolled 100 patients aged 35–42 to compare PGT-A with standard morphological embryo selection.
  • After up to three transfers, cumulative live-birth rates were 72% with PGT-A versus 52% without genetic testing.
  • Women assigned to PGT-A achieved pregnancy in fewer embryo transfers, indicating a faster time to conception.
  • The unblinded study was small and underpowered, and it deliberately included mosaic embryos that are common in practice but rarely studied.
  • Researchers called for larger multi-centre trials, noting that NICE does not recommend routine PGT-A and NHS provision is unchanged.