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7h ago

Pilot Trial Points to Faster IVF Success With Embryo Chromosome Testing for Women 35–42

Researchers report a preliminary benefit but seek confirmation before any change to UK guidance or NHS provision.

The average age of patients undergoing IVF treatment has risen for the past 50 years
Almost 21,000 babies were born from IVF in 2023, compared to 8,700 in 2000, the Human Fertilisation and Embryology Authority (HFEA) has said. (Photo by Philippe Lopez/AFP)
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Overview

  • A single-centre, unblinded pilot RCT at King's Fertility in London enrolled 100 women aged 35–42 and, unusually, included mosaic embryos often seen in routine practice.
  • After up to three transfers, the cumulative live-birth rate was 72% with preimplantation genetic testing for aneuploidy (PGT-A) versus 52% with standard morphological selection.
  • Women assigned to PGT-A became pregnant in fewer embryo transfers, indicating a shorter time to conception for this older age group.
  • Authors emphasize the study’s small sample and lack of statistical significance, calling for larger multi-centre trials to confirm the observed trends.
  • NICE does not recommend routine PGT-A and the test is not routinely available on the NHS, leaving many patients to pay privately pending stronger evidence.