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3w ago

Pilot RCT Signals Faster IVF Conception for Women 35–42 Using PGT-A

The small unblinded trial did not reach statistical significance, leaving clinical guidance unchanged.

The average age of patients undergoing IVF treatment has risen for the past 50 years
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Almost 21,000 babies were born from IVF in 2023, compared to 8,700 in 2000, the Human Fertilisation and Embryology Authority (HFEA) has said. (Photo by Philippe Lopez/AFP)
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Overview

  • Results published in the Journal of Clinical Medicine report a pilot randomized trial at King’s Fertility enrolling 100 women aged 35–42, split evenly between PGT-A and control arms.
  • After up to three embryo transfers, the cumulative live birth rate was 72% with PGT-A versus 52% without testing.
  • Participants who received PGT-A conceived in fewer transfers, indicating shorter time to pregnancy for this age group.
  • Researchers emphasize the findings show a promising trend rather than proof and call for larger multi‑centre trials to confirm effects.
  • The study uniquely included mosaic embryos and notes PGT-A remains a privately accessed IVF add‑on in the UK, with no routine NHS offering under current NICE guidance.