Overview

• Mac Jones started for the injured Brock Purdy and led a 1:46, five-completion, 59-yard march to set up the 35-yard game-winner.
• Arizona briefly moved ahead on a rare fourth-quarter tiebreaking safety, drawn by a Calais Campbell-forced holding penalty in the end zone.
• Nick Bosa exited in the first quarter with a knee injury and did not return, and Cardinals running back James Conner was carted off with an ankle injury.
• Jones finished 27-of-41 for 284 yards with a touchdown and an interception, with Christian McCaffrey adding 140 yards from scrimmage and Ricky Pearsall posting 117 receiving yards.
• San Francisco improved to 3-0 and leads the NFC West, while Arizona fell to 2-1 ahead of hosting Seattle on Thursday as the 49ers prepare to face Jacksonville.