Overview

• Even slight overdoses deplete glutathione, allowing the toxic byproduct NAPQI to build up and attack liver cells.
• Combining paracetamol with alcohol amplifies the risk of acute liver failure, even at doses only marginally above recommendations.
• Liver disease diagnoses have risen 40% in the past two decades while deaths have quadrupled to about 10,000 annually in the UK.
• Early-stage liver disease often shows only vague symptoms such as fatigue, nausea or jaundice, making it difficult to detect without medical testing.
• The British Liver Trust estimates 90% of cases can be prevented through moderate alcohol intake, a balanced diet, regular exercise and responsible medication use.