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PFAS Exposures Drive Cognitive Impairment as Gut Microbes Offer Removal Pathway

Demonstrating neurotoxic risks of both legacy and short-chain PFAS, the study reveals a bacterial mechanism for rapid chemical clearance.

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Overview

  • A Journal of Hazardous Materials study finds chronic low-level PFAS mixtures accumulate in mouse brains, cross the blood–brain barrier and disrupt memory, behavior and neuronal health.
  • University of Rochester researchers report that developmental PFHxA exposure causes long-term anxiety-related behaviors and memory deficits in adult male mice.
  • University of Cambridge scientists identify gut bacteria that absorb 25% to 74% of PFAS within minutes in humanized mice, significantly boosting faecal excretion.
  • While microbial PFAS sequestration shows promise for bioremediation, its efficacy and safety have not yet been tested in human trials.
  • Public health experts are calling for regulators to reevaluate safety limits and mitigation strategies for both short-chain and legacy PFAS in water and consumer products.