Overview

• AMP‑Diffusion generated roughly 50,000 antimicrobial peptide candidates, which were ranked and narrowed to 46 for synthesis using the APEX 1.1 filter.
• Laboratory testing showed 76% of the synthesized peptides inhibited bacteria, including multidrug‑resistant strains, with low toxicity.
• Two AI‑designed peptides treated skin infections in mice with efficacy comparable to levofloxacin and polymyxin B, without observable adverse effects.
• The system integrates Meta’s ESM‑2 protein language model during generation to produce biologically plausible sequences more efficiently.
• Authors describe a proof‑of‑concept and plan to steer designs toward specific pathogens and drug‑like properties, with funding sources and potential conflicts disclosed.