Overview

• University of Pennsylvania researchers report the AMP-Diffusion system in Cell Biomaterials, published September 2, 2025.
• The model generated roughly 50,000 antimicrobial peptide candidates, then an in‑lab tool called APEX 1.1 prioritized sequences for synthesis.
• Forty-six peptides were made and tested, and two cleared skin infections in mice with efficacy comparable to levofloxacin and polymyxin B.
• The peptides showed no detectable adverse effects in the animal studies, according to the authors.
• The team frames the work as proof of principle and plans to steer designs toward drug-like properties, with extensive preclinical development still required.