Overview
- Nick Bosa suffered a calf injury during Thursday practice and has been ruled out for Week 3 with the 49ers expecting him to miss multiple weeks, removing their top pass-rush threat for upcoming games.
- Giants quarterback Jaxson Dart was placed on injured reserve and will undergo knee surgery on Friday for meniscus and MCL damage, a procedure that the team says will sideline him for the rest of the regular season.
- The Dallas Cowboys formally ruled out four defenders—cornerback Cobie Durant and safeties Malik Hooker and P. J. Locke plus linebacker DeMarvion Overshown—who will not travel to Rio de Janeiro for Sunday’s game.
- Several other starters enter Week 3 with doubts or game-day questions, including Rams receiver Puka Nacua listed as doubtful with a hip issue, Saints RB Travis Etienne limited with a hamstring, Raiders TE Brock Bowers questionable with a knee, and the Panthers ruling Devin Lloyd, Claudin Cherelus and Nick Scott out.
- Teams are already responding with roster moves and plan shifts—expect more practice-squad promotions, short-term signings and schematic changes to generate rush and cover depth—which continues a larger trend of recurring injuries that has repeatedly interrupted the 49ers’ availability and will affect competitive balance in coming weeks.