Overview

• Two British Journal of Cancer studies assessed data from more than 340,000 women in England to validate the CA125-plus-age approach.
• The model showed its strongest performance in patients over 50, supporting more targeted urgent referral and specialist assessment.
• A linked economic evaluation found using the tool for over-50s would detect more cancers earlier within NICE affordability thresholds.
• Current GP practice refers for ultrasound only when CA125 crosses a fixed cutoff, which the age-adjusted risk score is designed to refine.
• Cancer Research UK and study authors urge prospective real-world testing and NHS readiness work before routine adoption.