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Osaka AI Model Detects Fatty Liver Disease in Routine Chest X-Rays

Validated in a large retrospective study, the model highlights a new route to low-cost, widespread screening that could catch liver disease earlier.

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Overview

  • The model was developed by Associate Professors Sawako Uchida-Kobayashi and Daiju Ueda at Osaka Metropolitan University’s Graduate School of Medicine.
  • Researchers trained the deep learning algorithm on 6,599 chest X-ray images from 4,414 patients, using controlled attenuation parameter scores as ground truth measures of liver fat.
  • It achieved an area under the receiver operating characteristic curve between 0.82 and 0.83, demonstrating reliable differentiation between patients with and without fatty liver disease.
  • Leveraging standard chest radiographs capitalizes on their widespread availability, low cost and reduced radiation compared with ultrasound, CT and MRI.
  • Published in Radiology: Cardiothoracic Imaging, the findings pave the way for prospective validation and integration of the tool into clinical workflows for early disease detection.