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Oral and Gut Microbes Offer Early Warning of Cognitive Decline in Parkinson’s

King’s College London researchers used AI to identify bacterial toxins that may flag patients at higher risk of dementia.

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Overview

  • A study of 228 saliva and stool samples from Parkinson’s patients and healthy individuals found harmful oral and gut bacteria increase with cognitive impairment.
  • Researchers led by King’s College London employed artificial intelligence to pinpoint toxins released by these bacteria that correlate with memory and learning decline.
  • The team proposes that virulence factors from oral bacteria may translocate to the gut, triggering inflammation and potentially damaging the brain.
  • Identified bacterial markers could be developed into early diagnostic tools to flag patients at elevated risk of dementia.
  • Scientists suggest that maintaining oral hygiene, a balanced diet, and targeted probiotic interventions may help slow neurodegenerative processes in Parkinson’s disease.