Overview
- Winfrey released Enough with Yale endocrinologist Dr. Ania M. Jastreboff, pairing personal experience with clinical guidance on obesity and weight-loss medications.
- In appearances on Today and The View, she said she regained about 20 pounds after stopping a GLP-1 for a year, concluding she needs the medication for maintenance.
- She described rapid relief from intrusive "food noise" on day one of treatment and compared continued use to staying on blood pressure medicine.
- Winfrey acknowledged past contributions to diet culture, calling the 1988 wagon-of-fat TV moment a major regret and urging an end to weight shaming.
- Conversations with Serena Williams on The Oprah Podcast highlighted shifting views on GLP-1s, from seeing them as a shortcut to discussing their role in care and stigma reduction.