Overview
- Winfrey says she stopped injections “cold turkey” in January 2024 for 12 months, kept up diet and exercise, regained about 20 pounds, and restarted after concluding long-term use was necessary.
- She reports the treatment curbed her desire for alcohol and that she has not had a drink in years.
- Since starting in 2023, she says she has lost roughly 50 pounds from a high of 237 pounds and no longer fixates on food.
- She cites prior pre-diabetes and high cholesterol, typically injects weekly but sometimes every 10–12 days, declines to name a brand, and manages mild digestive side effects with water and magnesium.
- Winfrey and obesity expert Dr. Ania M. Jastreboff co-wrote Enough, out Jan. 13, which presents obesity science and GLP-1s as a public-service guide; PEOPLE also notes pill versions are expected in early 2026.