Overview
- Winfrey’s new book, Enough, coauthored with Yale endocrinologist Dr. Ania M. Jastreboff, debuted Jan. 13 as she promoted it across CBS and NBC’s Today and on The Oprah Podcast.
- She says a GLP‑1 medication quieted intrusive “food noise” within hours and that she now views the drug as ongoing treatment after regaining about 20 pounds during a year off it.
- On Today, Winfrey cited constipation as her main side effect and said she manages it with water and magnesium, while Jastreboff outlined typical GLP‑1 effects like nausea, diarrhea and constipation.
- Winfrey publicly regrets being a “major contributor” to diet culture, writes that obesity is not a moral failing, and urges ending shame around weight and treatment choices.
- A podcast conversation with Serena Williams highlighted shifting attitudes, as Williams described resisting GLP‑1s as a ‘shortcut’ before embracing them after exhaustive efforts failed.