Overview
- In a new People cover story, Winfrey says the GLP-1 medication she began in 2023 reshaped her appetite and lifestyle, and she now works out about two hours six days a week.
- She reports the drug erased her urge to drink—"I haven’t had a drink in years"—which aligns with research that GLP-1s can dampen cravings for substances like alcohol.
- She stopped injections on her 70th birthday in January 2024 and, despite continuing diet and exercise, regained about 20 pounds over the following year.
- Winfrey expects to stay on GLP-1s long term, typically dosing weekly and sometimes every 10–12 days, and she describes only minor digestive side effects.
- She has co-written Enough with obesity expert Dr. Ania M. Jastreboff, due January 13, and recounts that at her 211-pound "Enough Point" she was pre-diabetic with high cholesterol.