Open-Label Placebos Found to Significantly Reduce PMS Symptoms

A University of Basel study reveals that placebo pills, even when transparently labeled, outperform standard treatments for PMS while raising questions about the placebo effect's mechanisms.

• The study involved 150 women aged 18-45 with moderate to severe PMS, divided into three groups: open-label placebos with explanation, placebos without explanation, and standard treatments.
• Participants taking open-label placebos with an explanation experienced the greatest symptom reduction (79%) and decreased life disruption (83%).
• Placebos without explanation also led to significant improvements, with a 50% reduction in symptom intensity and life interference.
• Standard treatments, including antidepressants and hormonal therapies, showed the least improvement, with only a 33% reduction in symptoms.
• Researchers emphasize the need for further studies to confirm the findings across broader populations and explore the mechanisms driving the placebo effect.

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