Particle.news
Download on the App Store

Oldest RNA Ever Sequenced Recovered From 40,000-Year-Old Woolly Mammoth

The Cell study captures a snapshot of muscle gene activity preserved by Siberian permafrost.

Overview

  • Researchers at Stockholm University and SciLifeLab sequenced RNA from the mammoth Yuka, setting a new age record for ancient RNA.
  • The transcripts reveal genes tied to muscle contraction and stress-related metabolism that were active shortly before the animal died.
  • Regulatory microRNAs were identified in the tissue, with some carrying mammoth-specific mutations that support authentic ancient origin.
  • Preservation proved rare across screened specimens, with only Yuka providing RNA of sufficient quality for detailed analysis.
  • Scientists say the finding expands paleogenomic tools to probe ancient physiology and potentially RNA viruses, contingent on similarly exceptional preservation.