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Obesity-Related Cancer Deaths Triple in U.S. Over Two Decades

Presented at ENDO 2025, the analysis highlights demographic disparities, regional gaps alongside urgent calls to address structural barriers to cancer prevention.

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Overview

  • Age-adjusted mortality from 13 obesity-linked cancers climbed from 3.73 to 13.52 per million people between 1999 and 2020.
  • Annual percent change in obesity-related cancer deaths averaged 5.92% overall and surged 19.37% from 2018 to 2020.
  • Women, adults aged 65 and older, Native Americans and Black Americans experienced the steepest rises in obesity-associated cancer mortality.
  • The Midwest recorded the highest regional rates while the Northeast remained lowest and states such as Vermont, Minnesota and Oklahoma topped the state rankings.
  • Researchers urge reframing obesity as a cancer prevention priority by expanding upstream interventions, ensuring universal screening and tackling structural health inequities.