Overview

• Huntsman Cancer Institute researchers report that hyperlipidemia alone accelerated triple-negative tumor growth in engineered mouse models, independent of high glucose or insulin.
• Reducing lipid levels slowed breast cancer cell proliferation even when glucose and insulin remained elevated in the mice.
• The findings were published in Cancer & Metabolism, and News-Medical reports the work was funded by the National Cancer Institute.
• The team plans preclinical tests of anti-lipid drugs, including combinations with chemotherapy, to evaluate whether lowering fats can blunt tumor progression.
• Investigators caution that very high-fat weight-loss regimens such as ketogenic diets could pose risks for patients with obesity and emphasize that confirmation in human studies is required before changing clinical guidance.