Overview

• Scientists discovered that transcription-driven motions of genes contribute to the complex movement within the genome.
• High-resolution imaging and CRISPR technology were used to visualize and analyze gene motions in live human cells.
• Active genes were found to drive genome motion in low-compaction regions, while compacted genomes influenced gene movement regardless of activity.
• The research highlights potential implications for understanding diseases linked to gene dysfunction, such as cancer and neurological disorders.
• The study provides new insights into the physics of active living systems, offering a deeper understanding of the human genome's organization.