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Novel Antibody Therapy Shows Promise in Rejuvenating Aging Immune Systems in Mice

A groundbreaking study reveals a potential pathway to revitalizing the immune systems of the elderly by targeting specific stem cells, with implications for human health.

Bacteria in the gut The human gut teems with bacteria and other microbes. They contribute to our health but also influence our susceptibility to certain diseases, including Alzheimer’s disease. https://www.flickr.com/photos/nihgov/53006111880/in/photolist-2oKYbmG-WQd7wM-U4kMcq-FtA56G-23FhBAr-VoAKx1-2gBBS3Z-xsQLKd-22eoPNH-2gfJrwn/
Medical illustration of 12 stem cells against a red background. Two of the stem cells appear larger in the foreground of the image and are in focus, while the others are blurred, along with the background. The stem cells appear like silver blobs with a red circular center
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Overview

  • A new immunotherapy targets hematopoietic stem cells to rebalance the immune system, making it more youthful in mice.
  • The treatment, developed by scientists at Stanford University and NIH, could potentially extend to humans, offering a way to combat age-related immune decline.
  • Older mice treated with the antibody showed a significant increase in adaptive immune cells and a decrease in pro-inflammatory markers.
  • The therapy's effects were durable, lasting up to 16 weeks, and improved the mice's response to vaccination.
  • Experts caution that while promising, further research is needed to understand potential human applications and long-term effects.