Novel Alzheimer's Treatment Shows Promise in Mice and Early Human Trials

A new approach using 40Hz light and sound stimulation has been found to slow Alzheimer's progression by enhancing the brain's waste removal system.

Researchers have discovered that 40Hz sensory gamma rhythm stimulation can reduce Alzheimer's disease progression by clearing amyloid proteins via the brain's glymphatic system.
The treatment involves exposing patients to lights flickering and sounds clicking at a frequency of 40Hz, which has shown cognitive benefits in both mice and early human trials.
The stimulation increases 40Hz power and synchrony in the brain, which in turn prompts neurons to release peptides that promote amyloid clearance.
Blocking the function of the aquaporin 4 water channel in astrocyte cells, which facilitates glymphatic fluid exchange, prevented the treatment's beneficial effects on amyloid levels and cognitive functions.
Further research is needed to fully understand the mechanisms behind this treatment and to determine its long-term effects on human cognition.