Overview
- The Lancet Diabetes & Endocrinology paper reports a harmonized reanalysis of DPPOS and DaQingDPOS, pooling more than 2,400 participants followed for roughly 20 to 30 years.
- Achieving sustained remission of prediabetes was associated with a 58% lower risk of cardiovascular death or hospitalization for heart failure.
- Rates of major adverse cardiovascular events, including heart attack and stroke, were 42% lower among participants who reached remission.
- Findings were consistent across the U.S. and Chinese studies, reinforcing that risk reduction tracks with normalized glucose rather than lifestyle programs alone.
- Researchers highlight a fasting glucose threshold of ≤97 mg/dL as a practical marker for lower risk and urge considering remission as a formal prevention target, while noting policy gaps cited in Germany.