Overview

• Men currently have only condoms or vasectomy as recognized contraceptive options.
• YCT-529 works by blocking a vitamin A derivative from binding its receptor to inhibit sperm production.
• A safety trial in 16 vasectomized volunteers found no concerning effects on heart rate, fertility hormones, sexual desire or mood, even at the highest dose.
• Preclinical animal studies showed that fertility returned within weeks after stopping YCT-529 treatment.
• The next phase will assess whether daily doses of YCT-529 effectively suppress spermatogenesis in healthy men.