Overview

• The randomized, double-blind, sham-controlled crossover trial enrolled 28 IBS patients who believed they benefited from a gluten-free diet and had them consume cereal bars with gluten, wheat or placebo in random order.
• Participants reported comparable symptom worsening across all three bar types, highlighting negative expectations rather than ingredients as the primary trigger.
• Stool sample analysis showed only about one-third of subjects adhered fully to the bar regimen, suggesting some skipped bars to avoid anticipated discomfort.
• Most participants maintained their dietary beliefs and gluten avoidance even after being told which bars caused their reported symptoms.
• Researchers recommend integrating psychological support and personalized management with dietary guidance to help IBS sufferers safely reintroduce gluten and wheat.