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16m ago

Nobel Prize in Medicine Awarded to Shimon Sakaguchi and U.S. Colleagues for Regulatory T Cell Discovery

The award caps decades of research on regulatory T cells, a field now steering advances in autoimmune disease, oncology, transplant tolerance.

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Overview

  • Sweden’s Karolinska Institute named Osaka University’s Shimon Sakaguchi, 74, and two U.S. researchers as the 2025 Physiology or Medicine laureates.
  • The prize recognizes the discovery and characterization of regulatory T cells that keep immune responses in check.
  • At a news conference in Osaka, Sakaguchi called the decision a pleasant surprise and expressed hope for progress toward clinical use.
  • The Prime Minister issued an official commendation citing advances in peripheral immune tolerance and pledged stronger support for basic science.
  • Past Nobel winners Shinya Yamanaka and Tasuku Honjo lauded the achievement, patient groups voiced hopes for new therapies, and the award ceremony is scheduled for December 10 in Stockholm.