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15m ago

No. 7 Oregon Hosts No. 15 USC With CFP Stakes on the Line

Oddsmakers have nudged the line to roughly Oregon -10 as USC’s prolific passing meets the Ducks’ nation‑leading pass defense.

USC wide receiver Makai Lemon makes a catch during the first half of their game against Northwestern on Friday, Nov. 7, 2025, at the Coliseum. (Photo by Harry How/Getty Images)
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EUGENE, OREGON - OCTOBER 25: Head coach of the Oregon Ducks Dan Lanning stands on the field during their game against the Wisconsin Badgers at Autzen Stadium on October 25, 2025 in Eugene, Oregon.
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Overview

  • Kickoff is 12:30 p.m. PT (3:30 p.m. ET) at Autzen Stadium on CBS, with streaming on Paramount+ and Fubo.
  • Both teams enter 6-1 in Big Ten play (Oregon 9-1, USC 8-2), and the winner strengthens its CFP case and positioning for a potential Big Ten title game berth.
  • Markets moved the spread from Oregon -8 to around -10/-10.5, reflecting broad media and betting support for the Ducks.
  • Key matchup features USC receivers Makai Lemon and Ja’Kobi Lane against Oregon’s top-ranked pass defense, while the Ducks’ powerful run game faces a Trojans front that has been vulnerable on the ground.
  • Notable injuries include USC RB Eli Sanders and CB Chasen Johnson listed out, with several Trojans questionable, while Oregon lists WR Evan Stewart and CB Trey McNutt out; USC’s LT Elijah Paige has been flagged as a potential absence by some analysts.