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38m ago

No. 7 Oregon Hosts No. 15 USC With CFP Hopes on the Line

Betting has swung toward Oregon by about 10 points in a strength-on-strength test between the Ducks’ top-tier pass defense and USC’s explosive air attack.

USC wide receiver Makai Lemon makes a catch during the first half of their game against Northwestern on Friday, Nov. 7, 2025, at the Coliseum. (Photo by Harry How/Getty Images)
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EUGENE, OREGON - OCTOBER 25: Head coach of the Oregon Ducks Dan Lanning stands on the field during their game against the Wisconsin Badgers at Autzen Stadium on October 25, 2025 in Eugene, Oregon.
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Overview

  • Kickoff is set for 12:30 p.m. PT / 3:30 p.m. ET at Autzen Stadium, with national TV coverage on CBS and streaming on Paramount+ and Fubo.
  • Books moved the spread from roughly Oregon -8 to -10/-10.5, reflecting growing market confidence in the Ducks.
  • Oregon enters with one of the nation’s best defenses, including the Big Ten’s top pass defense, against a USC offense ranked among the FBS leaders behind QB Jayden Maiava and receivers Makai Lemon and Ja’Kobi Lane.
  • Pregame injury reports list multiple USC and Oregon contributors as out or questionable, leaving key availability decisions to gameday.
  • USC’s recent road form is a concern, with a 1-6 mark at ranked opponents under Lincoln Riley and no Trojan win at Autzen since 2011.