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51m ago

No. 7 Oregon Hosts No. 15 USC in CFP-Shaping Autzen Test

Oddsmakers now favor Oregon by roughly 10 points because of its top-ranked pass defense.

USC wide receiver Makai Lemon makes a catch during the first half of their game against Northwestern on Friday, Nov. 7, 2025, at the Coliseum. (Photo by Harry How/Getty Images)
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EUGENE, OREGON - OCTOBER 25: Head coach of the Oregon Ducks Dan Lanning stands on the field during their game against the Wisconsin Badgers at Autzen Stadium on October 25, 2025 in Eugene, Oregon.
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Overview

  • Kickoff is set for Saturday at 3:30 p.m. ET on CBS as Oregon (9-1) welcomes USC (8-2) to Autzen Stadium.
  • Analysts frame the matchup as a de facto playoff filter, with the winner boosting its CFP path and a Ducks home loss viewed as especially damaging to their résumé.
  • Oregon enters with the nation’s No. 1 pass defense, drawing focus to how it handles USC’s explosive attack led by QB Jayden Maiava and receivers Makai Lemon and Ja’Kobi Lane.
  • The betting line has climbed from Oregon -8 to around -9.5/-10 across major sportsbooks, reflecting market confidence in the Ducks’ defense and home-field edge.
  • Injury reports list multiple USC absences and questionables, Oregon has several skill and line players banged up, and USC’s recent road record versus ranked teams plus a winless streak at Autzen since 2011 add context.