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NIH Study Confirms Alarming Rise in Early-Onset Cancer Cases in the U.S.

New analysis highlights significant increases in 14 cancer types among adults under 50, with breast, colorectal, kidney, and uterine cancers driving most cases.

FILE - A radiologist uses a magnifying glass to check mammograms for breast cancer in Los Angeles, May 6, 2010. (AP Photo/Damian Dovarganes, File)
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Overview

  • The incidence of early-onset cancers increased in 14 out of 33 cancer types studied between 2010 and 2019, with four types accounting for over 80% of the additional cases.
  • Breast cancer saw the largest absolute increase, with 4,800 additional cases in 2019 compared to 2010, followed by colorectal, kidney, and uterine cancers.
  • Rising obesity rates, changes in reproductive patterns, and improved cancer detection methods are being investigated as potential contributors to these trends.
  • Mortality rates for most early-onset cancers remain stable, but colorectal, uterine, testicular, and bone/joint cancers show concerning increases in death rates among younger adults.
  • The findings have already informed updates to screening guidelines, lowering the recommended ages for breast and colorectal cancer screenings to improve early detection.