Overview

• The randomized, double-blind crossover trial enrolled Werner syndrome patients in two 26-week phases comparing daily NR supplementation with placebo.
• Participants experienced significant blood NAD+ elevations during NR treatment without any serious adverse events.
• Arterial stiffness measures improved markedly under NR, signaling reduced cardiovascular risk.
• Chronic skin ulcer areas decreased substantially during supplementation, reflecting enhanced tissue repair.
• NR intake also corresponded with slower kidney function decline and lower metabolomic markers of renal impairment.