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58m ago

Nick Bosa Tears ACL, Will Miss 2025 Season After MRI Confirms Clean Right-Knee Injury

San Francisco plans a by-committee pass rush led by Bryce Huff.

Image
Sep 21, 2025; Santa Clara, California, USA; San Francisco 49ers defensive end Nick Bosa (97) on the field during warm ups prior to a game against the Arizona Cardinals during the first half at Levi's Stadium. Mandatory Credit: Cary Edmondson-Imagn Images
Nick Bosa #97 of the San Francisco 49ers stands on the sidelines during the national anthem prior to an NFL football game against the Arizona Cardinals at Levi's Stadium on September 21, 2025 in Santa Clara, California.
49ers quarterback Brock Purdy walks off the field after Sunday's 16-15 win over the Arizona Cardinals at Levi's Stadium, when he was ruled out of being the third emergency quarterback due to his toe injury. 

Overview

  • Imaging confirmed a clean torn ACL in Bosa’s right knee, requiring season-ending surgery and marking his second NFL ACL tear after a left-knee injury in 2020.
  • He was hurt late in the first quarter of a 16-15 win over the Cardinals, with initial sideline tests inconclusive before he exited after giving a thumbs-down.
  • Head coach Kyle Shanahan said the pass rush will be replaced by committee, with Bryce Huff expected to start off the edge as the 3-0 49ers enter Week 4.
  • Defensive-line health updates include DT C.J. West’s broken thumb requiring surgery with a possible return in a cast and rookie Mykel Williams listed day-to-day with a wrist injury.
  • The team is evaluating possible roster additions, and outside analysts have urged exploring trades or veteran free agents to reinforce the pass rush.