Overview
- The 49ers announced that Nick Bosa pulled his calf while warming up at Thursday practice and was ruled out for Sunday’s Week 3 game against the Arizona Cardinals.
- Coach Kyle Shanahan confirmed the calf was sustained during warmups, said Bosa will miss a few weeks, and added that the player is expected to return this season.
- San Francisco is weighing whether to place Bosa on injured reserve, a move that would require a minimum four-game absence and uses one of the team’s limited IR-return designations.
- The loss deepens a fragile front that has already lost multiple defensive linemen to long-term injuries, forcing short-term signings and heavier workloads for veterans such as Keion White and Osa Odighizuwa.
- Bosa’s setback follows his comeback from a season-ending 2025 ACL tear and removes the 49ers’ primary pass-rush threat for the near term, which could change play-calling, personnel usage, and game plans until he returns.