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Nick Bosa Out for Season With Torn ACL After MRI Confirms Clean Tear

A clean MRI finding shifts the 49ers’ edge workload to Bryce Huff with rookie Mykel Williams set for a larger role.

Sep 21, 2025; Santa Clara, California, USA; San Francisco 49ers defensive end Nick Bosa (97) on the field during warm ups prior to a game against the Arizona Cardinals during the first half at Levi's Stadium. Mandatory Credit: Cary Edmondson-Imagn Images
Nick Bosa #97 of the San Francisco 49ers stands on the sidelines during the national anthem prior to an NFL football game against the Arizona Cardinals at Levi's Stadium on September 21, 2025 in Santa Clara, California.
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SANTA CLARA, CALIFORNIA - SEPTEMBER 21: Kyler Murray #1 of the Arizona Cardinals scrambles away from the pressure of CJ West #99 of the San Francisco 49ers during the fourth quarter at Levi's Stadium on September 21, 2025 in Santa Clara, California. (Photo by Thearon W. Henderson/Getty Images)

Overview

  • Bosa injured his right knee late in the first quarter of Sunday’s 16-15 win over the Cardinals when he was double-teamed on a rush and exited after signaling a thumbs-down.
  • Imaging on Monday confirmed a clean ACL tear with no meniscus or additional ligament damage, and he will undergo season-ending surgery, according to multiple reports.
  • Coach Kyle Shanahan said initial sideline tests were inconclusive before the MRI, calling the result an isolated tear that typically allows a standard reconstruction and rehab.
  • This is Bosa’s second season-ending ACL injury of his NFL career, following a left-knee tear in Week 2 of the 2020 season.
  • Bosa posted a broken-heart emoji on Instagram as the 3-0 49ers, already dealing with injuries to Brock Purdy and George Kittle, turn to Huff, Williams and other linemen to fill the pass‑rush void.