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51m ago

Nick Bosa Leaves With Knee Injury in 49ers' 16-15 Win as Team Awaits MRI

San Francisco awaits MRI results to clarify the injury, leaving his Week 4 status uncertain.

Sep 21, 2025; Santa Clara, California, USA; San Francisco 49ers defensive end Nick Bosa (97) on the field during warm ups prior to a game against the Arizona Cardinals during the first half at Levi's Stadium. Mandatory Credit: Cary Edmondson-Imagn Images/File Photo
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Overview

  • Bosa injured his knee late in the first quarter against Arizona, went to the blue tent, gave a thumbs-down toward the stands, and was ruled out at halftime.
  • Kyle Shanahan said sideline exams did not indicate an ACL tear, but further evaluation including an MRI is planned and the team remains concerned based on how Bosa feels.
  • The 49ers improved to 3-0 with Eddy Piñeiro’s walk-off 35-yard field goal, with young defenders taking on larger roles after Bosa exited.
  • Rookie DE Mykel Williams briefly left with a wrist issue before returning, while DT C.J. West left with a thumb injury; other starters such as George Kittle and Brock Purdy have recently been out.
  • Bosa had one tackle Sunday after recording a sack in each of the first two games, and his prior 2020 season-ending ACL/MCL injury adds to concern about the new knee issue.