Overview

• Official NHS guidance says people taking sertraline should not consume grapefruit juice.
• Harvard Health explains that grapefruit furanocoumarins inhibit intestinal CYP3A4, which can push drug levels higher than expected.
• Similar caution applies to Seville (sour) oranges and tangelos, which contain related compounds, according to Harvard Health.
• The NHS also advises avoiding alcohol during sertraline treatment because it can stop the medicine working properly.
• Patients are told to check other medicines and supplements, with specific cautions for anticoagulants, NSAIDs, MAOIs and St John’s wort, and to consult a doctor before combining them.