Overview

• NHS guidance on its website says people who bought omeprazole without a prescription should not use it for longer than 14 days and should see a GP if symptoms worsen or do not improve.
• Reports cited in coverage link prolonged PPI use to higher risks including Clostridioides difficile infection, low magnesium after extended use, weakened bones, vitamin B12 deficiency, and other infections.
• Stopping omeprazole abruptly can cause a rebound increase in stomach acid, so patients are advised to manage discontinuation carefully.
• Administration advice includes taking doses at the same time each day, swallowing enteric or gastro‑resistant tablets and capsules whole, and asking a pharmacist for help if swallowing is difficult.
• Use is widespread, with about 73 million NHS prescriptions for PPIs dispensed in England in 2022–23 and research indicating around 15% of people use them.