The health service advises not to take ibuprofen at the same time as other NSAIDs, specifically naming aspirin and naproxen. Combining NSAIDs or using high doses long term increases the risk of gastrointestinal bleeding and kidney problems. Over‑the‑counter products, including some cough and cold remedies, may also contain NSAIDs, so labels should be checked to prevent duplication. Patients are told to consult a clinician before using ibuprofen if they take anticoagulants, blood‑pressure medicines, corticosteroids, certain antibiotics or antidepressants, sulfonylurea diabetes drugs, or herbal supplements such as ginkgo biloba. Urgent care or a call to NHS 111 is advised for warning signs like black stools, blood in vomit or urine, swelling in the ankles or hands, or not passing urine.
