Overview

• Guidance highlights bleeding risk for warfarin users taking regular or higher-dose paracetamol and advises sticking to the lowest effective dose.
• The NHS warns against taking paracetamol alongside other products that also contain it, such as some cold and flu remedies, due to overdose risk.
• People are told not to combine ibuprofen with other NSAIDs—including aspirin, diclofenac, celecoxib or naproxen—because of increased chances of stomach bleeding and kidney problems.
• Patients should tell their doctor about anticoagulants, blood‑pressure drugs, steroids, certain antibiotics or antidepressants, and diabetes medicines before using ibuprofen, and ginkgo biloba can also raise bleeding risk.
• Urgent help or a call to 111 is advised if symptoms such as dark stools, blood in vomit, swollen ankles, blood in urine or inability to urinate occur after taking ibuprofen.