Overview

• The Win-Glio trial at University College London Hospital’s NaNational Hospital for Neurology and Neurosurgery has opened for enrollment in the NIHR UCLH Clinical Research Facility.
• Participants will receive the CTLA-4 inhibitor ipilimumab prior to surgery, radiotherapy, and chemotherapy to harness their strongest immune response.
• Dame Siobhain McDonagh led a campaign that raised over £1 million in memory of her sister, Baroness Margaret McDonagh, who died of glioblastoma in 2023.
• Consultant oncologist Dr Paul Mulholland, who treated patient Ben Trotman, is heading the study after a previous ipilimumab trial closed due to low recruitment.
• Ben Trotman remains tumor-free more than two years after his pre-treatment dose of ipilimumab, underscoring the potential to extend the typical nine-month survival in glioblastoma.