Overview

• The NHS advises people taking amlodipine not to consume grapefruit or grapefruit juice because large amounts can increase the drug’s concentration and worsen side effects.
• The interaction occurs when grapefruit compounds block the CYP3A4 enzyme that normally helps metabolise amlodipine, leading to higher blood levels of the medicine.
• Patients are told to report increased symptoms such as dizziness, headaches, flushing, fainting or palpitations after consuming grapefruit while on amlodipine.
• Related fruits that may cause similar effects include Seville oranges, pomelos and tangelos, which the NHS says are best avoided during treatment.
• Amlodipine accounts for over 30 million prescriptions annually in the UK and millions take blood‑pressure medicines, with today’s coverage amplifying existing NHS advice rather than announcing new rules.