Overview
- Dr Amir Khan cautioned that prolonged use of proton pump inhibitors like omeprazole can reduce absorption of vitamin B12, magnesium and calcium.
- The reports highlight a higher risk of Clostridioides difficile infection and a short-term increase in pneumonia risk, with mixed evidence for longer-term pneumonia outcomes.
- Observational studies associate extended omeprazole use with bone fractures, kidney problems including chronic kidney disease, and fundic gland polyps.
- He advised patients not to stop the medication suddenly and to discuss any concerns with a GP or pharmacist.
- Suggested steps include prioritising nutrient-rich foods and considering GP-supervised dose reduction or intermittent use, with NHS guidance limiting over-the-counter use to two weeks without review.