Overview

• The NHS will prescribe Mounjaro to about 220,000 patients with a BMI over 40 and at least four obesity-related conditions over the next three years under new guidelines.
• The MHRA is investigating over 560 reports of pancreatitis linked to GLP-1 injections, including 10 fatalities, and has issued updated pregnancy and contraceptive warnings.
• Clinicians warn that mandatory blood screening for liver function, triglycerides and uncontrolled diabetes is essential to prevent organ failure in high-risk patients.
• A five-year Greater Manchester trial will enrol 3,000 tirzepatide users to evaluate impacts on weight loss, diabetes prevention, NHS use and return-to-work rates.
• Patients and experts report gastrointestinal distress and temporary hair loss as emerging side effects, prompting demands for nutritional guidance and comprehensive lifestyle support.