Overview

• Chicago, Green Bay, Atlanta and Pittsburgh sit out on their Week 5 byes, trimming the slate to 14 games.
• The Thursday opener features Los Angeles hosting San Francisco, with the 49ers noted to be without Brock Purdy.
• Two unbeaten teams play at home as Philadelphia faces Denver and Buffalo meets New England on Sunday night.
• Outlets publish straight‑up picks with confidence levels for the full schedule, reflecting shifting depth charts and early records.
• The NFL’s bye window runs from Weeks 5–14 with no byes in Week 13, keeping all 32 teams active over Thanksgiving weekend.