Overview

• The 14-game slate runs Oct. 2–6, opening with 49ers at Rams on Thursday Night Football and closing with Chiefs at Jaguars on Monday Night Football.
• Sunday features an international matchup in London with the Vikings facing the Browns on NFL Network in the early window.
• DraftKings lists the Rams as a 3-point favorite over the 49ers for Thursday night, with a 47.5 total and Rams -180 on the moneyline.
• BetMGM’s snapshot highlights several sizable spreads, including Lions -8.5 at the Bengals, Bills -8.5 hosting the Patriots, and Cardinals -9.5 against the Titans.
• AZ Central published game-by-game predictions for all matchups, including picks such as Rams over 49ers and Chiefs edging the Jaguars, while four teams are on bye: Falcons, Bears, Packers and Steelers.