Overview
- The Week 4 slate runs Sept. 25–29, starting with Seattle at Arizona on Thursday night and ending with Jets-Dolphins and Bengals-Broncos on a Monday doubleheader.
- Thursday Night Football streams exclusively on Prime Video from State Farm Stadium in Glendale.
- Published lines show Arizona -1.5 over Seattle with a total around 43.5, though numbers vary by sportsbook.
- Reports indicate Cardinals running back James Conner is out for the season with an ankle injury, placing Trey Benson in a larger role.
- Seattle is coming off a 44-13 Week 3 win over the Saints that allowed several starters to rest, as media outlets post early Week 4 picks and betting guidance across all 16 games.