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NFL Week 4 Set: Schedule, Streaming and Odds Lead Into Cardinals-Seahawks on TNF

Sportsbooks make Arizona a slight TNF favorite following James Conner’s reported season-ending ankle injury.

Overview

  • The Week 4 slate runs Sept. 25–29, starting with Seattle at Arizona on Thursday night and ending with Jets-Dolphins and Bengals-Broncos on a Monday doubleheader.
  • Thursday Night Football streams exclusively on Prime Video from State Farm Stadium in Glendale.
  • Published lines show Arizona -1.5 over Seattle with a total around 43.5, though numbers vary by sportsbook.
  • Reports indicate Cardinals running back James Conner is out for the season with an ankle injury, placing Trey Benson in a larger role.
  • Seattle is coming off a 44-13 Week 3 win over the Saints that allowed several starters to rest, as media outlets post early Week 4 picks and betting guidance across all 16 games.